
                         SEQUENCE LISTING

<110>  THE GENERAL HOSPITAL CORPORATION
       KWIATKOWSKI, JR., Thomas J.
       BROWN, JR., Robert H.
 
<120>  FUS/TLS-based compounds and methods for diagnosis, treatment and 
       prevention of amyotrophic lateral sclerosis and related motor 
       neuron diseases

<130>  M0765.70101WO00

<150>  US 61/135,689
<151>  2008-07-22

<160>  4     

<170>  PatentIn version 3.4

<210>  1
<211>  10115
<212>  DNA
<213>  Homo sapiens

<400>  1
aaaaaaagat aaaatgtcat cctcacatca gccttttgtt gtgaaaaata aaatcaagag     60

tttactcagt cagaacaggg cctgacagta agtcttgtta aagtgttagc tattacatat    120

tatagatgag cacaatgtat atcattatta aatgtcagct ttattattat tatttgtttt    180

gagacagtct tgctctgttg cccaggctgg agtgcagtgg cacgtcttgg ctcactgcaa    240

cttccgcctc ctgggttcaa gcgattctcc catctcagct tcctgagtag ctgggattac    300

agatgcgcgg acgacgcctg gctaattttt gtatttttag tagagacggg gtttcaccat    360

gttggccagg ctggtctcga actcctgacc tcgtgatcca cacgcctcgg cctcccaaag    420

tgctggtatt acaggcgtga gccaccgcac ccggtcagct ttattattaa atgttaactt    480

catctgcttt gtacacgaat gcatacccag tgcccagaac agtgcctgga acatactagg    540

tgctaaataa atatttgtga cttaatgcat gaataagggt ggacttcctt tcttttgctc    600

tcactggaga gttgaactct ccttccaaag gcggtggggt ggatattggc atattcaggg    660

cctttagggc tgaagtcaag ggcttagtgg ggcttaattt gtgggcgggc ccagggcatg    720

gccctcattg tttctctaga aagacgtgtc caaccctcaa aggaccttct gaaatcccgc    780

tgaaaggtta agttgggaag gaaaacctgc atgcctatgt atcaggaatt aacgtctttt    840

gtcttgtttt attcagtagt ttcaaattgc cttctccagg caaggctgat gaaagtgcaa    900

gttgcaagtt aatttgaatg tttctttttg cttttgctct cacaggaagt gaaaaggcga    960

ccaaacactc tagcattcat gccaccaaaa agaggagtgt tttgcagtta caagacctgg   1020

attcgaatca cgactcctct tagctgccct gtaatcaggc acaattactt gggtctctga   1080

gtctcacttt ccttatctag aaaacggagg tatctttact tccttcgtaa gactgatgac   1140

aaggaaatta tctgtgcatt ttgaaaccac ttaagccttg tacacgtttt atttctggga   1200

tcgccctggt agggcttcag aaaaataaaa aggaggtccc tgagaaaagg ctgggtaccg   1260

tacatctgag gtcaaccctc tctggtccca aggatggcct gggctgttcc gccccgtggc   1320

tccccagggg caaagccatg aggatccggg tgagagccca gtgctggacg agcccggggc   1380

ccaggggtcc cggccgaaat ccctgctgtc tttcaggtca aacgtcataa tccccgaacc   1440

ccagaaaggc cgaaaggcaa ggcaaccctg aaagacgacg aagtcaacct cagggcgcag   1500

gagagggagg gccagtgtgc tgccgacgag ggaggctgga gccgcgggga cgaggcgccc   1560

catacagcgg caagagggtg gagggcagga gctcgccatc ctgggtgaaa gcggggccca   1620

gcgaaggggc ccggccacag gaatctcggt tccaccccgc tactcccggc tgtgactcca   1680

gtttcgtccc cagccgccgg gaccgccccc tcgccccgcc cccagcgggc actcaggccg   1740

taccactgtg ccttcatggg ggtggagata gatcgtgggc tagtcctgcc gaggagagag   1800

gggttcttcc tcaaaaaata tgattatgta tagtattcgc atgattctag ttaacttgtt   1860

tcccttctgc ctgctcggac cctctacctg ccctacgaag ggggcggagt gcgttcctgc   1920

ctccccctgc tcttccgcgt ttggtgcgcg cctgcgcggt gcgtaggcgg cggagcgtac   1980

ttaagcttcg acgcaggagg gagagggagg gccagtgtgc tgccgacgag ggaggctgga   2040

gccgcgggga cgaggcgccc catacagcgg caagagggtg gagggcagga gctcgccatc   2100

ctgggtgaaa gcggggccca gcgaaggggc ccggccacag gaatctcggt tccaccccgc   2160

tactcccggc tgtgactcca gtttcgtccc cagccgccgg gaccgccccc tcgccccgcc   2220

cccagcgggc actcaggccg taccactgtg ccttcatggg ggtggagata gatcgtgggc   2280

tagtcctgcc gaggagagag gggttcttcc tcaaaaaata tgattatgta tagtattcgc   2340

atgattctag ttaacttgtt tcccttctgc ctgctcggac cctctacctg ccctacgaag   2400

ggggcggagt gcgttcctgc ctccccctgc tcttccgcgt ttggtgcgcg cctgcgcggt   2460

gcgtaggcgg cggagcgtac ttaagcttcg acgcaggagg cggggctgct cagtcctcca   2520

ggcgtcggta ctcagcggtg ttggaacttc gttgcttgct tgcctgtgcg cgcgtgcgcg   2580

gacatggcct caaacggtag gtaagggcgc gaggcgacgg cggcggcgca cccggccgag   2640

gcctcccagc tgggcttttc gttttcagtg ggaccggggc ggcgatcccg tgtgggattt   2700

tttggcgccc ctgtggcggg aagccgcgga gaagagtaac tggaggaggc tggtgtcgcc   2760

attttgtttc gctcctctgg ccctcgcgcg cggggcggga agtcttttct ttgcagtccg   2820

tttgcttggg gtgggcgttg ggagggacgc ttcttagggg tttgaagcgt caggtgaggg   2880

tggaaaacgc ccattctccg tggcctcgcc tcccccaact cccggccccg cgctcgagcc   2940

cgctttgtcg cagtgctgca tccgggcact cgcggcgcgc acgcgctctg cgggcccctc   3000

ccccttcgcg gcgcgggtac cccttccccg cctcgtgttg gttcagcttt ctgtcgcgag   3060

acccttcgcg gaagactcgg cggcgcgcgt ccggtgcccg gctaattttt tgtattttta   3120

ttagagatgg ggcttcacca tgttggtcag gccagtctcg aattcctgac ctcaagtgat   3180

ccacccacct cggcctccca aactgctggg attacaggca tgatccaccg tgcctggcct   3240

acgtggtcct ttttattcat cagtgcttga gttaaggaat ttagctttaa ttcaactctt   3300

tcagagtggc agctgaagat aatgtgattg tatttttctt ttgcagatta tacccaacaa   3360

gcaacccaaa ggtgagtgct atttttgggc ttccagagtt tgtagagggc aagggtggtc   3420

acgccatgtt ttctgatcac gctggttttc cttttattta gctatggggc ctaccccacc   3480

cagcccgggc agggctattc ccagcagagc agtcagccct acggacagca gagttacagt   3540

ggttatagcc agtccacgga cacttcaggc tatggccaga gcagctattc ttcttatggc   3600

cagagccaga acagtgagtc tttctcagcg ggtcacctct tcctactctt tctgaatatt   3660

gcttttcttt ttcttgtttt ttggagacgg agtctggtcc tgttgcccag gctggagtgc   3720

agtggtgctg tctcagctca ctgcaacatc agcctaccgg gttcaaacga ttctcctgcc   3780

tcagcctcct gagtagctgg gattacaggt acctgctacc acgcctggct aattttgtgt   3840

ttttagtaga gatggggttt cacgggtggt gctggagatg gtgttgggat tggcggggtg   3900

aaattggaac tgtactaaag agttggtaga agttgaagca ttaaatttag gctttgaaag   3960

gagggtaact atctttgcct atgagttgca acatcactaa cagcttctga gaggctggct   4020

ttatgagtat aggtattatg ttttctttaa cccattcctt acattttctc tttcctggtg   4080

gcttttgtga ctcccttttt cttatcctgg tagcaggcta tggaactcag tcaactcccc   4140

agggatatgg ctcgactggc ggctatggca gtagccagag ctcccaatcg tcttacgggc   4200

agcagtcctc ctaccctggc tatggccagc agccagctcc cagcagcacc tcgggaaggt   4260

acggtggtgt tgatgtcggg gaaggcttga aaagaggggt gaattgatga ggaatgataa   4320

agggaccagc agtaggagca gttcagaggt gtaattgggg taggggagcc tgtgttgggt   4380

acagagaatg gactccacta aaagtgaaag gaaattgggg gctatgctgg gattgtgatt   4440

gtgttttttg tttgttttcc ctagttacgg tagcagttct cagagcagca gctatgggca   4500

gccccagagt gggagctaca gccagcagcc tagctatggt ggacagcagc aaagctatgg   4560

acagcagcaa agctataatc cccctcaggg ctatggacag cagaaccagt acaacagcag   4620

cagtggtggt ggaggtggag gtggaggtgg aggtgagatg tcttcagctt tgtctgcagc   4680

ccattttctt tttctttttt tttttttttt tgagacggag tcttgctctg tctctgttgc   4740

tgaggctgga gtgcagtggc acaatctcgg ctcactgcaa gctccgcctt ccgggttcgc   4800

gccagtctcc tgcctcagcc tcccgagtag ctgggactac aggcatccgc caccacgccc   4860

ggctaatttt ttgtattttt agtagagacg gggtttcacc atcgccttgg cctcccaaag   4920

tgctgggatt acaggcgtga gccactgtgc ctggtgtctg cagcccattt tctataagga   4980

tttgtattct cctgttttag cttaaaagag ggttcctgtc ttgtttccta gctgtctttt   5040

tactttcttt tgtccttcat tgcctggcac ttgtcaaacc ttttcaaacc ttttagtgct   5100

actttacaat ctttttgttt ttttttttta atcattcttt cttttctcac aggtaactat   5160

ggccaagatc aatcctccat gagtagtggt ggtggcagtg gtggcggtta tggcaatcaa   5220

gaccagagtg gtggaggtgg cagcggtggc tatggacagc aggaccgtgg aggccgcggc   5280

aggggtggca gtggtggcgg cggcggcggc ggcggtggtg gttacaaccg cagcagtggt   5340

ggctatgaac ccagaggtcg tggaggtggc cgtggaggca gaggtggcat ggggtaggtg   5400

tctcatgagc cagggagtat ctttggtggg gagtgtggag gattgcatga atctccctga   5460

agccagtccc tagtgcatgg tttagtattc ttgttgtcta gggatctgtg agggctttga   5520

tttgggggca gtgactttct ttttacatcc ccattttatt tttgtgagaa cttgggagcc   5580

tgaactccca tccataccac tgaatagaga ttttgagtaa tgatacttgt ttccaaaaaa   5640

aaacagagga aatagataac gtaacctttt aaagcaaaat ctttataaac tgtgtctgag   5700

aaattgcaca cgtgtgtgtg acatgctcaa aggtcagaca aggggtggtc aggaagggat   5760

gtattttagt agccacttgt atctttttcc aaaaacacct acccatgttt ggggaatgtt   5820

aaacaaaatc aaaaaacaac cttttgtagc cgttggaagc ttcatgtcct ttcttctaac   5880

ttgtcttctc cagcggaagt gaccgtggtg gcttcaataa atttggtggt aagtgaacag   5940

agtttccaaa attcccaact cccagcaatg ctttgtctga ttgttcattt gcagatgtct   6000

tagcgtgtta atttaaatgt caaaggtttt gaggtgtcca gaaccacctc cagaaagggg   6060

tagggtagaa tgccacctgt tgcctggtgt gtgctaacct ggagcaggta ggggtaagac   6120

tcaatagtca tcttttacca aatgggtttg ccccaggtta ataagagggg tctagtagtt   6180

tgctgaagtg tggagttgtc tctgtggaga ctcaagttac agatcttaag gggcctgcct   6240

agaattttct cctctgggca ggcgacccag gaaagggttt ggagtgaggc tgtgagcact   6300

tacttgatat tttacaagtt tggatttggt gttaattttt ttccttgtcc gttttttcct   6360

gttgactaac ggctcatctt ttccttgttt ttgttttttt tttgttcttt ttttccatgt   6420

cactaaaggc cctcgggacc aaggatcacg tcatgactcc ggtgagttca cacgtggtgg   6480

catgaaaaga gtggctaaag tggtatcaag actgcctgga tgttctttga aactattata   6540

aaaaggaaac tgaaaaaaat ggggatagag aaggaaggga gttaggtgtg tccttagtta   6600

gcagtgagaa gtatttgtta cgaagtattt ctcagaaata cctggcttgt gggttccacc   6660

cccagtgatt taggtctgag aggaccctga aaatctacct ttctaacaag tactcctgag   6720

ccctggtttc catactgtat actgggtgtt aacatgtttc aaaggataat tgtcaaactg   6780

aatctgaaat ttatcagcat ggctggcata tagggactca aaagggatgt ggatttcttt   6840

ttagttgtct tccataaacc aaatgatacc agttgcttga tggatactag gtgctttagg   6900

ttttttcctg tgttttttat tttacctttt cacatttgca ttttctctgt tcaacaagca   6960

gaacaggata attcagacaa caacaccatc tttgtgcaag gcctgggtga gaatgttaca   7020

attgagtctg tggctgatta cttcaagcag attggtatta ttaaggtact tgtggagagg   7080

agtgggagct ttctgtcagt gttgtaggct tgtggatttc acacattagt aaaagcaagt   7140

ctttaatggt tgccagcagt aaaaacaagt cttagtggtt gttgccagct taatttgttg   7200

aggaaagagc cttagttact gttttctaaa agagaagttc tatcttaaca caaaaagtat   7260

aacttatcag agtaccctaa actcttgaga tttgtactct atagtaactt ttagttttat   7320

ctttcaatat tggagtgaga gacagttttc tttaatggag gtttacatgt gaggtaggaa   7380

gaagtaactg ggaagagggg agctgaagtt tgggaattat aaacctcatg ttctagagga   7440

agaagatgga aagggagtac tgtagccttt aaaattgatg ttacctcatt ttgctttctt   7500

cagacaaaca agaaaacggg acagcccatg attaatttgt acacagacag ggaaactggc   7560

aagctgaagg gagaggcaac ggtctctttt gatgacccac cttcagctaa agcagctatt   7620

gactggtttg atggtatgta tgagaaggct ggcagaggtg gggctgggga tatagggcag   7680

caagccttag gaaacaagcc atagtttgag ggttcttttg agtcttccaa cacttacttt   7740

agctgcggtt tcaggtagtc tcatttttgc ttatgtgtca gcagattata aaccatttga   7800

gaaaggcacg cttctcttgt attttcggat taatgtgtct tgcatttaaa gtctgttgat   7860

gattttttgt ttctctaggt aaagaattct ccggaaatcc tatcaaggtc tcatttgcta   7920

ctcgccgggc agactttaat cggggtggtg gcaatggtcg tggaggccga gggcgaggag   7980

gtgaggagct acctgctagt ggtgcagagg ggtaatgggg agagtgcaga agatggtaaa   8040

ggcttgcatg gaatgggtta gatttaccaa acttggagag ggagcagacc catacttggt   8100

ctatctgcat taggacccat gggccgtgga ggctatggag gtggtggcag tggtggtggt   8160

ggccgaggag gatttcccag tggaggtggt ggcggtggag gacagcagcg agctggtgac   8220

tggaagtgtc ctaatccgtg agtgaaactt aatttttttc ttagttctct tgcatgcgtg   8280

ctctttgata tattggtact gaggtatgtg cgtgttttcc aaagaagtaa atgtcaaggc   8340

cacactgttg gggtcagatt tagccaaaag cttacctagg taaggttgat gtaatgggaa   8400

aggtaatgga ttgggttcag taatactgat ttttgttcct gactctgaga agcaagccgt   8460

tttgtctttc tgaagcttca gtttcctcac tgtatctcta aagtcaccgt agtttcttcc   8520

tagttctagg tcttgcctat tccccatcgc tccagactga ttgtcttcct ttctccttag   8580

cacctgtgag aatatgaact tctcttggag gaatgaatgc aaccagtgta aggcccctaa   8640

accagatggc ccaggagggg gaccaggtgg ctctcacatg ggtaagaaag gcagacctgg   8700

tgctagggag ctgggaccaa agaatcctta atttttcagc ggggaggctc ggggaacata   8760

ggggaatggg aatatgatag atcttgtttc ttttgtccta gggggtaact acggggatga   8820

tcgtcgtggt ggcagaggag gctatgatcg aggcggctac cggggccgcg gcggggaccg   8880

tggaggcttc cgagggggcc ggggtggtgg ggacagaggt ggctttggcc ctggcaagat   8940

ggattccagg taagacttta aatcagaata aaaaagtaga gcagttgaac agaggccata   9000

ggataacagg gttttgttga gaaagtggtt tcattttgag ggctaggtgg aaagacctga   9060

ggttgtaacc agtagtggag agggaaggaa aattaactca gggggagtga atctgtagac   9120

ccacttgaga taagatactc gctgggttag gtaggagggg cagataggat atctaggctt   9180

ggagaggctg gtaactcaaa tataatggat acttaatttt tttttttttt tttgcagggg   9240

tgagcacaga caggatcgca gggagaggcc gtattaatta gcctggctcc ccaggttctg   9300

gaacagcttt ttgtcctgta cccagtgtta ccctcgttat tttgtaacct tccaattcct   9360

gatcacccaa gggttttttt gtgtcggact atgtaattgt aactatacct ctggttccca   9420

ttaaaagtga ccattttagt taaattttgt tcctcttccc ccttttcact ttcctggaag   9480

atcgatgtcc cgatcaggaa ggtagagagt tttcctgttc agattaccct gcccagcagg   9540

aactggaata cagtgttcgg ggagaaggcc aaatgatatc cttgagagca gagattaaac   9600

ttttctgtca tggggaaagt tggtgtataa atgagaaatg aagaacatgg gatgtcatga   9660

gtgttggcct aaatttgccc agctatgggg aatttttcct ttaccacatt tatttgcata   9720

ctggtcttag tttatttgca gcagtttatc cctttttaag aactctttga tcttttggcc   9780

cttttaatgg tgaggctcaa acaaactaca tttaaatggg gcagtattca gatttgacca   9840

tggtggagag cgcttagcca ctctgggtct ttcacaggaa ggagagtaac tgagtgctgc   9900

aggagtttgt ggagtggagt caggatctag gaggtgagtg actcccttcc tagctgccct   9960

ggtgaacagc gcttgggtag atacctgcta taaggagact ggtctggctg ggttactttc  10020

acatcctgcc tgtactcaga gggcttgagg tcattgacat tatgagattt taggcttgat  10080

ccctttttga ttggagggtg gaaggccctc ctaag                             10115


<210>  2
<211>  2002
<212>  DNA
<213>  Homo sapiens

<400>  2
cggggctgct cagtcctcca ggcgtcggta ctcagcggtg ttggaacttc gttgcttgct     60

tgcctgtgcg cgcgtgcgcg gacatggcct caaacgatta tacccaacaa gcaacccaaa    120

gctatggggc ctaccccacc cagcccgggc agggctattc ccagcagagc agtcagccct    180

acggacagca gagttacagt ggttatagcc agtccacgga cacttcaggc tatggccaga    240

gcagctattc ttcttatggc cagagccaga acacaggcta tggaactcag tcaactcccc    300

agggatatgg ctcgactggc ggctatggca gtagccagag ctcccaatcg tcttacgggc    360

agcagtcctc ctaccctggc tatggccagc agccagctcc cagcagcacc tcgggaagtt    420

acggtagcag ttctcagagc agcagctatg ggcagcccca gagtgggagc tacagccagc    480

agcctagcta tggtggacag cagcaaagct atggacagca gcaaagctat aatccccctc    540

agggctatgg acagcagaac cagtacaaca gcagcagtgg tggtggaggt ggaggtggag    600

gtggaggtaa ctatggccaa gatcaatcct ccatgagtag tggtggtggc agtggtggcg    660

gttatggcaa tcaagaccag agtggtggag gtggcagcgg tggctatgga cagcaggacc    720

gtggaggccg cggcaggggt ggcagtggtg gcggcggcgg cggcggcggt ggtggttaca    780

accgcagcag tggtggctat gaacccagag gtcgtggagg tggccgtgga ggcagaggtg    840

gcatgggcgg aagtgaccgt ggtggcttca ataaatttgg tggccctcgg gaccaaggat    900

cacgtcatga ctccgaacag gataattcag acaacaacac catctttgtg caaggcctgg    960

gtgagaatgt tacaattgag tctgtggctg attacttcaa gcagattggt attattaaga   1020

caaacaagaa aacgggacag cccatgatta atttgtacac agacagggaa actggcaagc   1080

tgaagggaga ggcaacggtc tcttttgatg acccaccttc agctaaagca gctattgact   1140

ggtttgatgg taaagaattc tccggaaatc ctatcaaggt ctcatttgct actcgccggg   1200

cagactttaa tcggggtggt ggcaatggtc gtggaggccg agggcgagga ggacccatgg   1260

gccgtggagg ctatggaggt ggtggcagtg gtggtggtgg ccgaggagga tttcccagtg   1320

gaggtggtgg cggtggagga cagcagcgag ctggtgactg gaagtgtcct aatcccacct   1380

gtgagaatat gaacttctct tggaggaatg aatgcaacca gtgtaaggcc cctaaaccag   1440

atggcccagg agggggacca ggtggctctc acatgggggg taactacggg gatgatcgtc   1500

gtggtggcag aggaggctat gatcgaggcg gctaccgggg ccgcggcggg gaccgtggag   1560

gcttccgagg gggccggggt ggtggggaca gaggtggctt tggccctggc aagatggatt   1620

ccaggggtga gcacagacag gatcgcaggg agaggccgta ttaattagcc tggctcccca   1680

ggttctggaa cagctttttg tcctgtaccc agtgttaccc tcgttatttt gtaaccttcc   1740

aattcctgat cacccaaggg tttttttgtg tcggactatg taattgtaac tatacctctg   1800

gttcccatta aaagtgacca ttttagttaa attttgttcc tcttccccct tttcactttc   1860

ctggaagatc gatgtcccga tcaggaaggt agagagtttt cctgttcaga ttaccctgcc   1920

cagcaggaac tggaatacag tgttcgggga gaaggccaaa tgatatcctt gagagcagag   1980

attaaacttt tctgtcatgg gg                                            2002


<210>  3
<211>  1581
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcctcaa acgattatac ccaacaagca acccaaagct atggggccta ccccacccag     60

cccgggcagg gctattccca gcagagcagt cagccctacg gacagcagag ttacagtggt    120

tatagccagt ccacggacac ttcaggctat ggccagagca gctattcttc ttatggccag    180

agccagaaca caggctatgg aactcagtca actccccagg gatatggctc gactggcggc    240

tatggcagta gccagagctc ccaatcgtct tacgggcagc agtcctccta ccctggctat    300

ggccagcagc cagctcccag cagcacctcg ggaagttacg gtagcagttc tcagagcagc    360

agctatgggc agccccagag tgggagctac agccagcagc ctagctatgg tggacagcag    420

caaagctatg gacagcagca aagctataat ccccctcagg gctatggaca gcagaaccag    480

tacaacagca gcagtggtgg tggaggtgga ggtggaggtg gaggtaacta tggccaagat    540

caatcctcca tgagtagtgg tggtggcagt ggtggcggtt atggcaatca agaccagagt    600

ggtggaggtg gcagcggtgg ctatggacag caggaccgtg gaggccgcgg caggggtggc    660

agtggtggcg gcggcggcgg cggcggtggt ggttacaacc gcagcagtgg tggctatgaa    720

cccagaggtc gtggaggtgg ccgtggaggc agaggtggca tgggcggaag tgaccgtggt    780

ggcttcaata aatttggtgg ccctcgggac caaggatcac gtcatgactc cgaacaggat    840

aattcagaca acaacaccat ctttgtgcaa ggcctgggtg agaatgttac aattgagtct    900

gtggctgatt acttcaagca gattggtatt attaagacaa acaagaaaac gggacagccc    960

atgattaatt tgtacacaga cagggaaact ggcaagctga agggagaggc aacggtctct   1020

tttgatgacc caccttcagc taaagcagct attgactggt ttgatggtaa agaattctcc   1080

ggaaatccta tcaaggtctc atttgctact cgccgggcag actttaatcg gggtggtggc   1140

aatggtcgtg gaggccgagg gcgaggagga cccatgggcc gtggaggcta tggaggtggt   1200

ggcagtggtg gtggtggccg aggaggattt cccagtggag gtggtggcgg tggaggacag   1260

cagcgagctg gtgactggaa gtgtcctaat cccacctgtg agaatatgaa cttctcttgg   1320

aggaatgaat gcaaccagtg taaggcccct aaaccagatg gcccaggagg gggaccaggt   1380

ggctctcaca tggggggtaa ctacggggat gatcgtcgtg gtggcagagg aggctatgat   1440

cgaggcggct accggggccg cggcggggac cgtggaggct tccgaggggg ccggggtggt   1500

ggggacagag gtggctttgg ccctggcaag atggattcca ggggtgagca cagacaggat   1560

cgcagggaga ggccgtatta a                                             1581


<210>  4
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser Asn Asp Tyr Thr Gln Gln Ala Thr Gln Ser Tyr Gly Ala 
1               5                   10                  15      


Tyr Pro Thr Gln Pro Gly Gln Gly Tyr Ser Gln Gln Ser Ser Gln Pro 
            20                  25                  30          


Tyr Gly Gln Gln Ser Tyr Ser Gly Tyr Ser Gln Ser Thr Asp Thr Ser 
        35                  40                  45              


Gly Tyr Gly Gln Ser Ser Tyr Ser Ser Tyr Gly Gln Ser Gln Asn Thr 
    50                  55                  60                  


Gly Tyr Gly Thr Gln Ser Thr Pro Gln Gly Tyr Gly Ser Thr Gly Gly 
65                  70                  75                  80  


Tyr Gly Ser Ser Gln Ser Ser Gln Ser Ser Tyr Gly Gln Gln Ser Ser 
                85                  90                  95      


Tyr Pro Gly Tyr Gly Gln Gln Pro Ala Pro Ser Ser Thr Ser Gly Ser 
            100                 105                 110         


Tyr Gly Ser Ser Ser Gln Ser Ser Ser Tyr Gly Gln Pro Gln Ser Gly 
        115                 120                 125             


Ser Tyr Ser Gln Gln Pro Ser Tyr Gly Gly Gln Gln Gln Ser Tyr Gly 
    130                 135                 140                 


Gln Gln Gln Ser Tyr Asn Pro Pro Gln Gly Tyr Gly Gln Gln Asn Gln 
145                 150                 155                 160 


Tyr Asn Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Asn 
                165                 170                 175     


Tyr Gly Gln Asp Gln Ser Ser Met Ser Ser Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Tyr Gly Asn Gln Asp Gln Ser Gly Gly Gly Gly Ser Gly Gly Tyr 
        195                 200                 205             


Gly Gln Gln Asp Arg Gly Gly Arg Gly Arg Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Tyr Asn Arg Ser Ser Gly Gly Tyr Glu 
225                 230                 235                 240 


Pro Arg Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly Met Gly Gly 
                245                 250                 255     


Ser Asp Arg Gly Gly Phe Asn Lys Phe Gly Gly Pro Arg Asp Gln Gly 
            260                 265                 270         


Ser Arg His Asp Ser Glu Gln Asp Asn Ser Asp Asn Asn Thr Ile Phe 
        275                 280                 285             


Val Gln Gly Leu Gly Glu Asn Val Thr Ile Glu Ser Val Ala Asp Tyr 
    290                 295                 300                 


Phe Lys Gln Ile Gly Ile Ile Lys Thr Asn Lys Lys Thr Gly Gln Pro 
305                 310                 315                 320 


Met Ile Asn Leu Tyr Thr Asp Arg Glu Thr Gly Lys Leu Lys Gly Glu 
                325                 330                 335     


Ala Thr Val Ser Phe Asp Asp Pro Pro Ser Ala Lys Ala Ala Ile Asp 
            340                 345                 350         


Trp Phe Asp Gly Lys Glu Phe Ser Gly Asn Pro Ile Lys Val Ser Phe 
        355                 360                 365             


Ala Thr Arg Arg Ala Asp Phe Asn Arg Gly Gly Gly Asn Gly Arg Gly 
    370                 375                 380                 


Gly Arg Gly Arg Gly Gly Pro Met Gly Arg Gly Gly Tyr Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Arg Gly Gly Phe Pro Ser Gly Gly Gly Gly 
                405                 410                 415     


Gly Gly Gly Gln Gln Arg Ala Gly Asp Trp Lys Cys Pro Asn Pro Thr 
            420                 425                 430         


Cys Glu Asn Met Asn Phe Ser Trp Arg Asn Glu Cys Asn Gln Cys Lys 
        435                 440                 445             


Ala Pro Lys Pro Asp Gly Pro Gly Gly Gly Pro Gly Gly Ser His Met 
    450                 455                 460                 


Gly Gly Asn Tyr Gly Asp Asp Arg Arg Gly Gly Arg Gly Gly Tyr Asp 
465                 470                 475                 480 


Arg Gly Gly Tyr Arg Gly Arg Gly Gly Asp Arg Gly Gly Phe Arg Gly 
                485                 490                 495     


Gly Arg Gly Gly Gly Asp Arg Gly Gly Phe Gly Pro Gly Lys Met Asp 
            500                 505                 510         


Ser Arg Gly Glu His Arg Gln Asp Arg Arg Glu Arg Pro Tyr 
        515                 520                 525     










